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notalwaysright_feedRead Rounding Down For The Holidays
Customer: "What are the chances that y’all will get some prime tenderloin in for Christmas?"
Me: "Well, sir, since we are open for a few more hours and closed tomorrow, being Christmas Day, I would say 0% chance."
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sixbeforelunchWhat if there’s no ethical way to have unlimited access to every book, film, and record ever created? And moreover, what if that’s not something we should want?
What if we simply decided to consume less media, allowing us to have a deeper appreciation for the art we choose to spend our time with? What if, instead of having an on-demand consumer mindset that requires us to systematically strip art of all its human context, we developed better relationships with creators and built new structures to support them? What if we developed a politics of refusal — the ability to say enough is enough — and recognized that we aren’t powerless to the whims of rich tech CEOs who force this dystopian garbage down our throats while claiming it’s “inevitable?”
Tapes and other physical media aren’t a magic miracle cure for late-stage capitalism. But they can help us slow down and remember what makes us human. Tapes make music-listening into an intentional practice that encourages us to spend time connecting with the art, instead of frantically vibe-surfing for something that suits our mood from moment-to-moment. They reject the idea that the point of discovering and listening to music is finding the optimal collection of stimuli to produce good brain chemicals.
notalwaysright_feedRead Don’t Invite Chris To The Office Holiday Party!
Religious Coworker: "Not one of you?! Oh, come on, they're beautiful reminders about the real reason we all celebrate this time of year! It's the first five letters of Christmas that make it important!"
Other Coworker: "Five? So, it's all about Chris?"
starwatcher posting in ![[community profile]](https://www.dreamwidth.org/img/silk/identity/community.png){kind=small}
fandom_checkinHow are you doing?
I am OK.
17 (77.3%)
I am not OK, but don't need help right now.
5 (22.7%)
I could use some help.
0 (0.0%)
How many other humans live with you?
I am living single.
7 (33.3%)
One other person.
8 (38.1%)
More than one other person.
6 (28.6%)
allthingshorror_feedSo, let me preface this with the fact that I've seen this movie discussed to hell and back and for the longest time I just didn't see the hype, I had watched it one time a while back and it just didn't strike me as anything special and as a matter of fact I thought it was kind of awful. The acting was pretty bad, the plot didn't make a whole lot of sense, the pacing was all over the place, I felt nothing for the characters at all because they were all just straight up annoying.
So it had always been surprising to me that everyone seemed to love it so much, though this isn't the only movie that I've had a hard time grasping the appeal for, a couple of other movies are VVitch, and The Lighthouse, not that they're bad movies but I just didn't get the hype and I found both to be pretty boring. At least the acting in those movies was on point though, Martyrs was just atrocious. Well, reading through one of the more recent Martyrs threads someone had mentioned how bad the American remake was in comparison to the original French film, it was at that point that I realized I may have in fact only watched the American remake, although I could've sworn I'd seen the French film. Thankfully both versions are up on Tubi, so I threw on the original French film to give it a re-watch and see if I was missing something.
Yeah I was missing something alright, I'm a fucking idiot, apparently this whole time I'd only seen the American remake and I had in fact never seen the French film. Now I can understand why people say to just watch the French version, holy shit that movie was wild, the acting was on point, I actually felt something for the characters. Not only that but the story made sense and was so incredibly bleak, it really might be one of the best "horror" movies I've ever seen. Well, after watching that I decided to throw on the American remake just to see if it was really as bad as I'd remembered it to be, fuck it may have even been worse than I remembered. How in the fuck did they botch it so hard?
It really baffles me that they took such an amazing movie and turned it into whatever the fuck the remake was, it was a pile of hot garbage. What's funny is this isn't even the first time that this has happened to me, I'd heard a ton of hype about the movie Oldboy and somehow I didn't catch that there were two versions so I ended up watching the American version. To be fair to that film though, it was at least coherent and I enjoyed it for the most part, I also ended up finding out that there was a Korean version and it was of course far superior but the American flick was at least watchable and entertaining with some flaws. The Martyrs remake was just downright awful for lack of something more descriptive.
So if you haven't seen Martyrs or if you're an idiot like me who has only seen the American version, do yourself a favor and watch the French film, it's so fucking good.
notalwaysright_feedRead From This Season Sprouts Unreason
Customer: "Oi! You've run out of the brussel sprouts!"
Me: "Well, it's Christmas Eve, mate."
Customer: "What have you done with them all?!"
sidereaBy examining both human Alzheimer's brain tissue and multiple preclinical mouse models, the team identified a key biological failure at the center of the disease. They found that the brain's inability to maintain normal levels of a critical cellular energy molecule called NAD+ plays a major role in driving Alzheimer's. Importantly, maintaining proper NAD+ balance was shown to not only prevent the disease but also reverse it in experimental models.
Why This Approach Differs From Supplements
Dr. Pieper cautioned against confusing this strategy with over the counter NAD+-precursors. He noted that such supplements have been shown in animal studies to raise NAD+ to dangerously high levels that promote cancer. The method used in this research relies instead on P7C3-A20, a pharmacologic agent that helps cells maintain healthy NAD+ balance during extreme stress, without pushing levels beyond their normal range.
NAD+ levels naturally decline throughout the body, including the brain, as people age. When NAD+ drops too low, cells lose the ability to carry out essential processes needed for normal function and survival. The researchers discovered that this decline is far more severe in the brains of people with Alzheimer's. The same pattern was seen in mouse models of the disease.Note, potential conflict of interest: the head of the lab, Dr Pieper, above, has a serious commercial interest in this proving out:
[...]
Amyloid and tau abnormalities are among the earliest and most significant features of Alzheimer's. In both mouse models, these mutations led to widespread brain damage that closely mirrors the human disease. This included breakdown of the blood-brain barrier, damage to nerve fibers, chronic inflammation, reduced formation of new neurons in the hippocampus, weakened communication between brain cells, and extensive oxidative damage. The mice also developed severe memory and cognitive problems similar to those seen in people with Alzheimer's.
[...]
This approach built on the group's earlier work published in Proceeding of the National Academy of Sciences USA, which showed that restoring NAD+ balance led to both structural and functional recovery after severe, long-lasting traumatic brain injury. In the current study, the researchers used a well-characterized pharmacologic compound called P7C3-A20, developed in the Pieper laboratory, to restore NAD+ balance.
The results were striking. Preserving NAD+ balance protected mice from developing Alzheimer's, but even more surprising was what happened when treatment began after the disease was already advanced. In those cases, restoring NAD+ balance allowed the brain to repair the major pathological damage caused by the genetic mutations.
Both mouse models showed complete recovery of cognitive function. This recovery was also reflected in blood tests, which showed normalized levels of phosphorylated tau 217, a recently approved clinical biomarker used to diagnose Alzheimer's in people. These findings provided strong evidence of disease reversal and highlighted a potential biomarker for future human trials.
The technology is currently being commercialized by Glengary Brain Health, a Cleveland-based company co-founded by Dr. Pieper.The actual research article:
Abstract:Full text here: https://www.cell.com/cell-reports-medicine/fulltext/S2666-3791(25)00608-1
Alzheimer's disease (AD) is traditionally considered irreversible. Here, however, we provide proof of principle for therapeutic reversibility of advanced AD. In advanced disease amyloid-driven 5xFAD mice, treatment with P7C3-A20, which restores nicotinamide adenine dinucleotide (NAD+) homeostasis, reverses tau phosphorylation, blood-brain barrier deterioration, oxidative stress, DNA damage, and neuroinflammation and enhances hippocampal neurogenesis and synaptic plasticity, resulting in full cognitive recovery and reduction of plasma levels of the clinical AD biomarker p-tau217. P7C3-A20 also reverses advanced disease in tau-driven PS19 mice and protects human brain microvascular endothelial cells from oxidative stress. In humans and mice, pathology severity correlates with disruption of brain NAD+ homeostasis, and the brains of nondemented people with Alzheimer's neuropathology exhibit gene expression patterns suggestive of preserved NAD+ homeostasis. Forty-six proteins aberrantly expressed in advanced 5xFAD mouse brain and normalized by P7C3-A20 show similar alterations in human AD brain, revealing targets with potential for optimizing translation to patient care.
case posting in fandomsecrets
allthingshorror_feedI watched Krampus and Better Watch Out, and they were my favorite Christmas horror movies. Can you recommend any other scary movies to watch on Christmas Eve?
allthingshorror_feedHas anyone else seen this series? I recently binged watched it from start to beginning and I am absolutely obsessed. The horror is right up my alley. Subtle scares with minimal jumpscares, and a very fresh/unique take on hell, demons and folklore (spoilers just in case). It's been a minute since I've seen something horror related that genuinely scared me.
You can watch any episode out of order as they are a stand alone, but I highly recommend watching it in order as there is an unravelling overlaying plot.
I think my favourite part is how high quality it is and how much effort was put into it. New sets of actors for each episode (whom all give excellent, believable performances), different locations and filming styles, but still cohesive enough to be set in the same universe.
Has anyone else seen the full series? If so, which were your favourites? Mine has to be Film Inferno, TAKE100, No Fiction, and Basement.
kaberett... which meant I thought it was very funny when later said afternoon I became aware that there's ongoing scrutiny of their operations from the Business and Trade Committee (first link I could find, it's bedtime). Also very funny that the time from name change to shed legacy of being Awful to Nah You're Still Awful was approximately -5, on a more national scale than I'd previously clocked...
thawreckaA cat adopts Jill, in canon typical fashion.
settiai
notalwaysright_feedRead Boss, Have Yourself A Merry Little Snickers
Boss: "Can you work on Christmas Eve?"
Me: "I mean, I'd rather not?
Boss: "We've had callouts. Please? There'll be a bonus for you."
Me: "A bonus? Like, money?"
Boss: "Well… no. But I can give you a coupon for a free candy bar from the vending machine."
allthingshorror_feedHey everyone! Spending the holidays alone this year and I’m looking for suggestions of horror movies that take place in Christmas or the holidays in general! Thanks :)
notalwaysright_feed - Rounding Down For The Holidaysslaymesoftly - Happy Holidays and Merry Christmassixbeforelunch - shared without commentxkcd_feed - Sauropodsnotalwaysright_feed - Don’t Invite Chris To The Office Holiday Party!jenab - Merry Christmas and Happy Holidays!starwatcher in fandom_checkin - Daily Check-Inallthingshorror_feed - Martyrs (2008), Holy shit that was insanity.notalwaysright_feed - From This Season Sprouts Unreasonallthingshorror_feed - A24 Films ‘Under the Skin,’ ‘Hereditary,’ ‘Pearl,’ and ‘Eighth Grade’ Are Getting Live Orchestra Scrsiderea - Merry Christmas: Scientists reverse Alzheimer's in mice [sci/bio/med]case in fandomsecrets - [ SECRET POST #6928 ]allthingshorror_feed - Any good Christmas horror movies?allthingshorror_feed - Fake Documetary Q, probably the scariest and most well put together Youtube series I've seenkaberett - today EVRi actually managed to deliver a parcel, not only on time but earlythawrecka - (no subject)allthingshorror_feed - Brandon Rogers horror spoof is funny af🤣settiai - The Mighty Nein 1x08notalwaysright_feed - Boss, Have Yourself A Merry Little Snickersallthingshorror_feed - Christmas themed movies?
