Daily Happiness

Dec. 24th, 2025 07:48 pm
torachan: arale from dr slump with a huge grin on her face (arale)
[personal profile] torachan
1. I'm so glad I decided to work from home today after all. The rain was really steady all day and I'm glad I wasn't out driving in it.

2. It had rained a bit overnight and was raining slightly when I went for my walk this morning, but I managed not to get very wet at all. Then I almost immediately hopped in the car to go down to Gardena and pick up the Christmas cake. It was raining a bit on the way down and then there was a sudden downpour right before I got to the bakery, but it stopped before I arrived. Got my cake and had almost no rain on the way back, but then it really let loose as soon as I was a few blocks from home lol. I had to dash in the house, but at least then I didn't have to go out anymore.

3. There was a few hour break in the rain in the late afternoon and early evening, so we got some more walking done and were able to take the trash out to the outside bins (Thursday is our usual trash day but of course they're not going to pick up until Friday this week; still, we like to get everything out on schedule, especially since we'll be out all day tomorrow).

4. When the rain was only drizzly this afternoon, the doorbell rang and I assumed it was a package, but it was the little boy across the street who was bringing homemade gifts to all the neighbors. Not sure if everyone was getting the same, but we got some chocolate coated Chex mix. Tasty! And very nice of them.

5. I forgot to mention yesterday but we did get the car back. I really wanted to get it back before the holidays and before the rain, so it was good timing. Hopefully nothing else goes wrong with either car for a while.

6. Look at Ollie all tucked in! That's actually not a blanket covering him, or rather, it's a wearable blanket with a hood. It's been very cozy now that the temps are down, but when I'm not wearing it, I leave it folded up on my bed and the cats just love to lie on it. (Or under it, in Ollie's case last night, though that was my doing. He did stay there, though.)

Review: Machine

Dec. 24th, 2025 07:05 pm
[syndicated profile] eaglespath_feed

Review: Machine, by Elizabeth Bear

Series: White Space #2
Publisher: Saga Press
Copyright: October 2020
ISBN: 1-5344-0303-5
Format: Kindle
Pages: 485

Machine is a far-future space opera. It is a loose sequel to Ancestral Night, but you do not have to remember the first book to enjoy this book and they have only a couple of secondary characters in common. There are passing spoilers for Ancestral Night in the story, though, if you care.

Dr. Brookllyn Jens is a rescue paramedic on Synarche Medical Vessel I Race To Seek the Living. That means she goes into dangerous situations to get you out of them, patches you up enough to not die, and brings you to doctors who can do the slower and more time-consuming work. She was previously a cop (well, Judiciary, which in this universe is mostly the same thing) and then found that medicine, and specifically the flagship Synarche hospital Core General, was the institution in all the universe that she believed in the most.

As Machine opens, Jens is boarding the Big Rock Candy Mountain, a generation ship launched from Earth during the bad era before right-minding and joining the Synarche, back when it looked like humanity on Earth wouldn't survive. Big Rock Candy Mountain was discovered by accident in the wrong place, going faster than it was supposed to be going and not responding to hails. The Synarche ship that first discovered and docked with it is also mysteriously silent. It's the job of Jens and her colleagues to get on board, see if anyone is still alive, and rescue them if possible.

What they find is a corpse and a disturbingly servile early AI guarding a whole lot of people frozen in primitive cryobeds, along with odd artificial machinery that seems to be controlled by the AI. Or possibly controlling the AI.

Jens assumes her job will be complete once she gets the cryobeds and the AI back to Core General where both the humans and the AI can be treated by appropriate doctors. Jens is very wrong.

Machine is Elizabeth Bear's version of a James White Sector General novel. If one reads this book without any prior knowledge, the way that I did, you may not realize this until the characters make it to Core General, but then it becomes obvious to anyone who has read White's series. Most of the standard Sector General elements are here: A vast space station with rings at different gravity levels and atmospheres, a baffling array of species, and the ability to load other people's personalities into your head to treat other species at the cost of discomfort and body dysmorphia. There's a gruff supervisor, a fragile alien doctor, and a whole lot of idealistic and well-meaning people working around complex interspecies differences. Sadly, Bear does drop White's entertainingly oversimplified species classification codes; this is the correct call for suspension of disbelief, but I kind of missed them.

I thoroughly enjoy the idea of the Sector General series, so I was delighted by an updated version that drops the sexism and the doctor/nurse hierarchy and adds AIs, doctors for AIs, and a more complicated political structure. The hospital is even run by a sentient tree, which is an inspired choice.

Bear, of course, doesn't settle for a relatively simple James White problem-solving plot. There are interlocking, layered problems here, medical and political, immediate and structural, that unwind in ways that I found satisfyingly twisty. As with Ancestral Night, Bear has some complex points to make about morality. I think that aspect of the story was a bit less convincing than Ancestral Night, in part because some of the characters use rather bizarre tactics (although I will grant they are the sort of bizarre tactics that I could imagine would be used by well-meaning people using who didn't think through all of the possible consequences). I enjoyed the ethical dilemmas here, but they didn't grab me the way that Ancestral Night did. The setting, though, is even better: An interspecies hospital was a brilliant setting when James White used it, and it continues to be a brilliant setting in Bear's hands.

It's also worth mentioning that Jens has a chronic inflammatory disease and uses an exoskeleton for mobility, and (as much as I can judge while not being disabled myself) everything about this aspect of the character was excellent. It's rare to see characters with meaningful disabilities in far-future science fiction. When present at all, they're usually treated like Geordi's sight: something little different than the differential abilities of the various aliens, or even a backdoor advantage. Jens has a true, meaningful disability that she has to manage and that causes a constant cognitive drain, and the treatment of her assistive device is complex and nuanced in a way that I found thoughtful and satisfying.

The one structural complaint that I will make is that Jens is an astonishingly talkative first-person protagonist, particularly for an Elizabeth Bear novel. This is still better than being inscrutable, but she is prone to such extended philosophical digressions or infodumps in the middle of a scene that I found myself wishing she'd get on with it already in a few places. This provides good characterization, in the sense that the reader certainly gets inside Jens's head, but I think Bear didn't get the balance quite right.

That complaint aside, this was very fun, and I am certainly going to keep reading this series. Recommended, particularly if you like James White, or want to see why other people do.

The most important thing in the universe is not, it turns out, a single, objective truth. It's not a hospital whose ideals you love, that treats all comers. It's not a lover; it's not a job. It's not friends and teammates.

It's not even a child that rarely writes me back, and to be honest I probably earned that. I could have been there for her. I didn't know how to be there for anybody, though. Not even for me.

The most important thing in the universe, it turns out, is a complex of subjective and individual approximations. Of tries and fails. Of ideals, and things we do to try to get close to those ideals.

It's who we are when nobody is looking.

Followed by The Folded Sky.

Rating: 8 out of 10

[syndicated profile] scalziwhatever_feed

Posted by John Scalzi

My senior year of college, I was invited by the Dartmouth Alumni Magazine to come and write a story about the college’s Green Key Weekend, a weekend of partying and games and partying and also partying with partying on the side (why did they invite me? Because I was from the famously unfun University of Chicago, and they wanted to see what the weekend looked like from the view of an outsider with that sort of perspective).

There was much of the weekend I don’t remember (ahem), but one thing that sticks in my mind is the Spring Sing concert, in which the several acapella groups of Dartmouth got together and did their thing. I thought they were all fantastic, and also, during the concert there was one girl who took a penny, balanced it on the end of a stretched-out wire coat hanger and spun it, keeping it stuck on the end of that coat hanger while singing the Toy R’ Us jingle, backward. I remember thinking this was the most hilariously amazing thing I’d ever seen, and also, I wanted to marry that girl, whoever she was.

Spoiler: I did not marry her. But neither has a year gone by that I have not thought about her and wondered what she was doing with her life now. We don’t always pick the things we remember. They make an impression nevertheless.

It is perhaps this personal history with acapella that primed me to enjoy Pitch Perfect as much as I did. It is a very silly film about something that doesn’t have much consequence, namely, the hyper-competitive college acapella circuit. This is obscure to the real world (or was, until this film), but is life-or-death to the theater-adjacent-kids who yearn to get out and sing without instrumental accompaniment. I first watched Pitch Perfect not expecting much, and came away having laughed more than I thought I would, and having been unexpectedly moved in a couple of places.

The plot: Beca (Anna Kendrick) is a jaded wanna-be DJ attending Barden University, mostly because her dad’s on the faculty so presumably she’s getting a tuition discount. She mostly wants to work at the college radio station and focus on her remixes, but one day Chloe (Brittany Snow) hears her singing in the shower and basically dragoons her into auditioning for the Barton Bellas, a once-proud all-girl acapella group now struggling because of an infamous event at the previous year’s national competition (which I will not relate, you will see it soon enough if you watch the film).

Beca auditions, gets in and immediately butts heads with Aubrey (Anna Camp), the group’s type-a leader, who wants to do things just so. Beca wants to loosen things up, whether everyone else agrees or not, and eventually there’s a battle of wills for the future of the group, interspersed with various competitions and run-ins with the Treblemakers, Barden’s all-male acapella group, who include Jesse (Skylar Astin), a fellow freshman who is sweet on Beca more than Beca is sweet on him.

Truth to tell, Beca is not a hugely sympathetic main character, even if she is played winningly by Kendrick. Beca gets a lot of mileage out of not being a joiner and being her own person, but mostly it just means she’s unhappy and maybe a little miserable to be around, and causes more trouble than needs to be caused. This is not bad for the movie, since it precipitates at least a couple of amusing scenes (including an acapella rumble, which is as ridiculous as it sounds). It does make you wonder what everyone in this film sees in her. Usually when someone is this casually dismissive of everyone and everything, you just let them get on with being their own little ball of gloom.

But no, the film and its characters are determined to pull her out of her shell, mostly because otherwise there wouldn’t be much of a movie, but also because they intuit that Beca’s lone wolf act is just that, an act. She likes being part of a group, and having friends, and being someone that others can rely on. The question for the movie is whether all of that can be achieved through the power of song, and whether Beca’s own particular set of musical skills will come into play. Inasmuch as this is a crowd-pleasing comedy, you will get no points for guessing how it’s all going to turn out.

No points, but that doesn’t mean it’s not still fun and even affecting. Acapella doesn’t mean anything in the real world, but there are worse things to get wrapped up in as a college-age person, and there’s something to be said about the joy you can have, getting into the same groove as all your friends. This movie is a jukebox musical and all the music is diegetic, but when you’re with a group of people who will naturally burst into song just because they feel like it, that diegetic nature doesn’t feel materially different from a standard musical. There’s something winning about a bunch of people just singing because, you know, why not? Why not sing? Even Beca eventually gives in to it. The power of pop compels her!

Naturally this all leads up to the movie’s final musical performance, where Beca has come up with a way to bring the underdog Bellas back to glory. I don’t know enough about the state of collegiate acapella in the early 2010s to know if what occurs here is an actual innovation or just the film reinventing the musical wheel, but at that point I also didn’t care. It’s a banger of a performance, so full of music nerd energy that I couldn’t help but smile all the way through it, and maybe even tear up (I am a weeper, deal with it). As musical payoffs go, it’s a winner.

Does the world change because of it? Not really, no. But not everything has to change the world. Sometimes just saving a dour little freshman from her own self-imposed alienation is enough. And in the meantime, the movie packs in a lot of snark along with the songs, thanks to a fun script, a very funny supporting cast (including Rebel Wilson in her star-making role), and a greek chorus in the form of two acapella color commentators (John Michael Higgins and Elizabeth Banks, the latter of whom also produced, and who would direct the sequel). It even made a pop star out of Anna Kendrick, as “Cups,” a version of a song she performed in the film, went to number 6 on the Billboard Hot 100 chart.

Pitch Perfect was a moderate-sized hit at the box office and blossomed in home video. Its two successors were box office smashes and there was even a TV series spin-off that detailed the adventures of a Treblemaker named Bumper (Adam DeVine) following up a fluke hit in Germany. None of these quite had the magic of the original, but they didn’t have to have that full measure of magic. Turns out people just seem to enjoy low-stakes comedy with a lot of music thrown in. I’m somewhat surprised that this film hasn’t yet been turned into a Broadway musical. If ever there was a property designed for the a long Broadway run as a tourist favorite followed by an eternal life as a touring show, it is this one. I suspect it’s a question of when, not if.

I watch Pitch Perfect when I need a little pick-me-up, because it’s fun, it has music, and inevitably it makes me smile. I suspect I am not alone in this assessment; I imagine every single acapella kid ever feels the same way, up to and including that penny-swinging, backwards-Toys-R-Us-theme-song singing girl. I know she’s still out there. I bet she loves this film to death.

— JS

(PS: If you want to read that story I wrote about Dartmouth’s Green Key Weekend, 34 years ago now, it’s here.)

Advent Calendar: Tea

Dec. 24th, 2025 10:16 pm
settiai: (Tea -- cool_spectrum)
[personal profile] settiai
Considering the state of my finances this year, I wasn't expecting to be able to get the Adagio advent calendar for December. Someone sent me a gift card as an early Christmas present, though, so I got to stick with the tradition after all.

It was 24 days for a total of 24 different teas, and - as usual - they tried to provide a fairly nice mix of very different types of teas. Some were great, some very much weren't, but they were all definitely different.

Teas under the cut. )
[syndicated profile] atlinguistic_feed


allthingslinguistic:

“Rudolph the Red-Nosed Reindeer” in Anglo-Saxon meter, by Philip Craig Chapman-Bell. Via Etymonline on Facebook, who says “An Internet classic; but I can no longer find it where I first found it (Cathy Ball’s Old English reference pages).”

Incipit gestis Rudolphi rangifer tarandus

Hwæt, Hrodulf readnosa hrandeor –
Næfde þæt nieten unsciende næsðyrlas!
Glitenode and gladode godlice nosgrisele.
Ða hofberendas mid huscwordum hine gehefigodon;
Nolden þa geneatas Hrodulf næftig
To gomene hraniscum geador ætsomne.
Þa in Cristesmæsseæfne stormigum clommum,
Halga Claus þæt gemunde to him maðelode:
“Neahfreond nihteage nosubeorhtende!
Min hroden hrædwæn gelæd ðu, Hrodulf!”
Ða gelufodon hira laddeor þa lyftflogan –
Wæs glædnes and gliwdream; hornede sum gegieddode
“Hwæt, Hrodulf readnosa hrandeor,
Brad springð þin blæd: breme eart þu!”

Rendered literally into modern English:

Here begins the deeds of Rudolph, Tundra-Wanderer

Lo, Hrodulf the red-nosed reindeer –
That beast didn’t have unshiny nostrils!
The goodly nose-cartilage glittered and glowed.
The hoof-bearers taunted him with proud words;
The comrades wouldn’t allow wretched Hrodulf
To join the reindeer games.
Then, on Christmas Eve bound in storms
Santa Claus remembered that, spoke formally to him:
“Dear night-sighted friend, nose-bright one!
You, Hrodulf, shall lead my adorned rapid-wagon!”
Then the sky-flyers praised their lead-deer –
There was gladness and music; one of the horned ones sang
“Lo, Hrodulf the red-nosed reindeer,
Your fame spreads broadly, you are renowned!”

Seasons' Greetings 2025 (Gregorian)

Dec. 24th, 2025 09:52 pm
dewline: Exclamation: "Hear, Hear!" (celebration)
[personal profile] dewline
I think that I've said this elsewhere: whatever you're celebrating or otherwise observing at this time of year, I hope that the Occasion(s) will be kind to you and yours.

Leaving it at that for tonight.

'Tis the season.

Dec. 24th, 2025 06:38 pm
rogueslayer452: (Summer Glau. Squee!)
[personal profile] rogueslayer452
₊˚。⋆❆⋆。˚₊ ₊˚。⋆❅⋆。˚₊ ₊˚。⋆❆⋆。˚₊ ₊˚。⋆❅⋆。˚₊ ₊˚。⋆❆⋆。˚₊ ₊˚。⋆❅⋆。˚₊
🎄 Merry Christmas and Happy Holidays 🎄
₊˚。⋆❅⋆。˚₊ ₊˚。⋆❆⋆。˚₊ ₊˚。⋆❅⋆。˚₊ ₊˚。⋆❆⋆。˚₊ ₊˚。⋆❅⋆。˚₊ ₊˚。⋆❆⋆。˚₊


Wishing everyone a wonderful and peaceful time this holiday season, and even if you don't celebrate I hope you have a good day regardless. ❤

Saint Norwegian Cod Day

Dec. 24th, 2025 05:55 pm
mildred_of_midgard: (bowiesmirk)
[personal profile] mildred_of_midgard
Ugh, I am so busy! I owe Yuletide comments, among other things.

But since this is mostly copy-pasting, I thought I'd do it...

Remember a couple years ago when I explained how my wife and I celebrate St. Salmon's Day on December 24 by eating salmon?

Furthermore, since my wife likes some of the Christmas trappings more than I do (tree, decorations, gift exchange, ritual meal), but is also an atheist who does not celebrate actual Christmas, we decided to call December 24 Salmon Day, because that is the day she makes our annual salmon (Brazilians celebrate Christmas on Dec 24). We were wishing each other a happy Salmon Day yesterday, and then today I wished her a happy "Day after Salmon Day," and she joked, "We are devotees of St. Salmon," and now Dec 25 is "Day after St. Salmon's Day" by sheer accretion of inside jokes. :D

This year, since she's living in Brazil again, she's visiting family for Xmas dinner, and we had this exchange on WhatsApp yesterday:

Her: i hope saint salmon doesn't get mad at me, I'm eating a different fish tomorrow
Me: We have made many offerings to St. Salmon, I'm sure you will be forgiven!


Then today:

Me: Happy Saint Other Fish's Day! 🤭
Her: happy saint fish's day to you too!
Me: You'll have to let me know what saint this is the day of.
Her: it is Norwegian cod day!
Her: in souffle format
Her: it is very holy
Her: 👀
Me: Happy Saint Norwegian Cod Day!


And later, after the dinner:
Her: damn, the cod souffle was amazing

I laughed a lot. Now back to work for me!

shared without comment

Dec. 24th, 2025 08:41 pm
sixbeforelunch: casette tapes, no text (cassette tapes)
[personal profile] sixbeforelunch
What if there’s no ethical way to have unlimited access to every book, film, and record ever created? And moreover, what if that’s not something we should want?

What if we simply decided to consume less media, allowing us to have a deeper appreciation for the art we choose to spend our time with? What if, instead of having an on-demand consumer mindset that requires us to systematically strip art of all its human context, we developed better relationships with creators and built new structures to support them? What if we developed a politics of refusal — the ability to say enough is enough — and recognized that we aren’t powerless to the whims of rich tech CEOs who force this dystopian garbage down our throats while claiming it’s “inevitable?”

Tapes and other physical media aren’t a magic miracle cure for late-stage capitalism. But they can help us slow down and remember what makes us human. Tapes make music-listening into an intentional practice that encourages us to spend time connecting with the art, instead of frantically vibe-surfing for something that suits our mood from moment-to-moment. They reject the idea that the point of discovering and listening to music is finding the optimal collection of stimuli to produce good brain chemicals.


Why I Quit Streaming And Got Back Into Cassettes by Janus Rose

Daily Check-In

Dec. 24th, 2025 05:58 pm
starwatcher: Western windmill, clouds in background, trees around base. (Default)
[personal profile] starwatcher posting in [community profile] fandom_checkin
 
This is your check-in post for today. The poll will be open from midnight Universal or Zulu Time (8pm Eastern Time) on Wednesday, December 24, to midnight on Thursday, December 25. (8pm Eastern Time).

Poll #34005 Daily Check-in
This poll is closed.
Open to: Access List, detailed results viewable to: Access List, participants: 22

How are you doing?

I am OK.
17 (77.3%)

I am not OK, but don't need help right now.
5 (22.7%)

I could use some help.
0 (0.0%)

How many other humans live with you?

I am living single.
7 (33.3%)

One other person.
8 (38.1%)

More than one other person.
6 (28.6%)




Please, talk about how things are going for you in the comments, ask for advice or help if you need it, or just discuss whatever you feel like.


If you're celebrating, may you all have a great day tomorrow -- and even if you're not celebrating, have a great day.
 

Yuletide: My Present!

Dec. 24th, 2025 06:44 pm
senmut: Yuletide Treasure with a silver ornament (General: Yuletide)
[personal profile] senmut
New Skills (1668 words) by Anonymous
Chapters: 1/1
Fandom: Moon is a Harsh Mistress - Robert A. Heinlein
Rating: Teen And Up Audiences
Warnings: No Archive Warnings Apply
Characters: Manuel Garcia O'Kelly Davis, Sidris (The Moon is a Harsh Mistress), Mimi, Greg, Bernardo de la Paz
Additional Tags: Pre-Canon
Summary:

Takes place just after Manny loses his arm



OMG OMG OMG, YES! This fic!
siderea: (Default)
[personal profile] siderea
2025 Dec 24: ScienceDaily [press release?]: "Scientists reverse Alzheimer’s in mice and restore memory":
By examining both human Alzheimer's brain tissue and multiple preclinical mouse models, the team identified a key biological failure at the center of the disease. They found that the brain's inability to maintain normal levels of a critical cellular energy molecule called NAD+ plays a major role in driving Alzheimer's. Importantly, maintaining proper NAD+ balance was shown to not only prevent the disease but also reverse it in experimental models.
WARNING WARNING WARNING: Yes, there are OTC supplements for tinkering with your NAD+, but they are apparently/allegedly CARCINOGENIC (cause CANCER) at typical doses. DO NOT run out and do something stupid. Tinkering with your whole-body cellular metabolism has some gnarly failure modes. From this article:
Why This Approach Differs From Supplements

Dr. Pieper cautioned against confusing this strategy with over the counter NAD+-precursors. He noted that such supplements have been shown in animal studies to raise NAD+ to dangerously high levels that promote cancer. The method used in this research relies instead on P7C3-A20, a pharmacologic agent that helps cells maintain healthy NAD+ balance during extreme stress, without pushing levels beyond their normal range.
Continuing from the article:
NAD+ levels naturally decline throughout the body, including the brain, as people age. When NAD+ drops too low, cells lose the ability to carry out essential processes needed for normal function and survival. The researchers discovered that this decline is far more severe in the brains of people with Alzheimer's. The same pattern was seen in mouse models of the disease.

[...]

Amyloid and tau abnormalities are among the earliest and most significant features of Alzheimer's. In both mouse models, these mutations led to widespread brain damage that closely mirrors the human disease. This included breakdown of the blood-brain barrier, damage to nerve fibers, chronic inflammation, reduced formation of new neurons in the hippocampus, weakened communication between brain cells, and extensive oxidative damage. The mice also developed severe memory and cognitive problems similar to those seen in people with Alzheimer's.

[...]

This approach built on the group's earlier work published in Proceeding of the National Academy of Sciences USA, which showed that restoring NAD+ balance led to both structural and functional recovery after severe, long-lasting traumatic brain injury. In the current study, the researchers used a well-characterized pharmacologic compound called P7C3-A20, developed in the Pieper laboratory, to restore NAD+ balance.

The results were striking. Preserving NAD+ balance protected mice from developing Alzheimer's, but even more surprising was what happened when treatment began after the disease was already advanced. In those cases, restoring NAD+ balance allowed the brain to repair the major pathological damage caused by the genetic mutations.

Both mouse models showed complete recovery of cognitive function. This recovery was also reflected in blood tests, which showed normalized levels of phosphorylated tau 217, a recently approved clinical biomarker used to diagnose Alzheimer's in people. These findings provided strong evidence of disease reversal and highlighted a potential biomarker for future human trials.
Note, potential conflict of interest: the head of the lab, Dr Pieper, above, has a serious commercial interest in this proving out:
The technology is currently being commercialized by Glengary Brain Health, a Cleveland-based company co-founded by Dr. Pieper.
The actual research article:

2025 Dec 22: Cell Reports Medicine [peer-reviewed scientific journal]: Pharmacologic reversal of advanced Alzheimer's disease in mice and identification of potential therapeutic nodes in human brain by Kalyani Chaubey et al. (+35 other authors!):
Abstract:

Alzheimer's disease (AD) is traditionally considered irreversible. Here, however, we provide proof of principle for therapeutic reversibility of advanced AD. In advanced disease amyloid-driven 5xFAD mice, treatment with P7C3-A20, which restores nicotinamide adenine dinucleotide (NAD+) homeostasis, reverses tau phosphorylation, blood-brain barrier deterioration, oxidative stress, DNA damage, and neuroinflammation and enhances hippocampal neurogenesis and synaptic plasticity, resulting in full cognitive recovery and reduction of plasma levels of the clinical AD biomarker p-tau217. P7C3-A20 also reverses advanced disease in tau-driven PS19 mice and protects human brain microvascular endothelial cells from oxidative stress. In humans and mice, pathology severity correlates with disruption of brain NAD+ homeostasis, and the brains of nondemented people with Alzheimer's neuropathology exhibit gene expression patterns suggestive of preserved NAD+ homeostasis. Forty-six proteins aberrantly expressed in advanced 5xFAD mouse brain and normalized by P7C3-A20 show similar alterations in human AD brain, revealing targets with potential for optimizing translation to patient care.
Full text here: https://www.cell.com/cell-reports-medicine/fulltext/S2666-3791(25)00608-1

[ SECRET POST #6928 ]

Dec. 24th, 2025 06:59 pm
case: (Default)
[personal profile] case posting in [community profile] fandomsecrets

⌈ Secret Post #6928 ⌋

Warning: Some secrets are NOT worksafe and may contain SPOILERS.


01.


More! )


Notes:

Secrets Left to Post: 01 pages, 177 secrets from Secret Submission Post #989.
Secrets Not Posted: [ 0 - broken links ], [ 0 - not!secrets ], [ 0 - not!fandom ], [ 0 - too big ], [ 0 - repeat ].
Current Secret Submissions Post: here.
Suggestions, comments, and concerns should go here.
kaberett: Trans symbol with Swiss Army knife tools at other positions around the central circle. (Default)
[personal profile] kaberett

... which meant I thought it was very funny when later said afternoon I became aware that there's ongoing scrutiny of their operations from the Business and Trade Committee (first link I could find, it's bedtime). Also very funny that the time from name change to shed legacy of being Awful to Nah You're Still Awful was approximately -5, on a more national scale than I'd previously clocked...

(no subject)

Dec. 25th, 2025 10:51 am
thawrecka: (Default)
[personal profile] thawrecka
The Yuletide collection had a glitch this morning where half the authors revealed way too early, but now that everything's gone back anon I'll link the gift fic I got:

Cat Distribution System (3809 words) by Anonymous
Chapters: 1/1
Fandom: Pet Shop of Horrors (Manga)
Rating: Teen And Up Audiences
Warnings: No Archive Warnings Apply
Relationships: Jill (Pet Shop of Horrors) & Leon Orcott (Pet Shop of Horrors)
Characters: Jill (Pet Shop of Horrors), Leon Orcot, Count D (Pet Shop of Horrors), Original Animal Character(s)
Additional Tags: 1990s Era is its own character honestly, The Dirtbag 1990s, Stalking (light), Period Typical Attitudes
Summary:

A cat adopts Jill, in canon typical fashion.



It's cute!

I ended up writing fewer Yuletide fics than last year, between holidays in November and exhaustion, and I feel weirdly guilty about it, but I appreciate the earlier opening gives me time to browse the collection before I head off to family Christmas Day hell 🤣

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